871 poster Combination of the EGFR-tyrosine kinase inhibitor ZD1839 (gefitinib, Iressa) and ionizing irradiation in glioma cell lines
- Book ID
- 119516349
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 245 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0167-8140
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High expression of the epidermal growth factor receptor (EGFR) in breast carcinoma confers a growth advantage to the tumor cells. The EGFR tyrosine kinase inhibitor (EGFR-TKI) ZD1839 ('Iressa') has clinical activity in a wide range of tumor types, although the mechanism(s) by which it exerts its ant
Overexpression of the growth factor receptors EGFR and erbB2 occurs frequently in several human cancers and is associated with aggressive tumour behaviour and poor patient prognosis. We have investigated the effects of ZD1839 (Iressa), a novel EGFR tyrosine kinase inhibitor, on the growth, in vitro