The protective effect of erdosteine against ototoxicity induced by cisplatin in rats
β Scribed by M. Tayyar Kalcioglu; Ahmet Kizilay; Mukaddes Gulec; Erkan Karatas; Mustafa Iraz; Omer Akyol; Mucahit Egri; Orhan Ozturan
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 361 KB
- Volume
- 262
- Category
- Article
- ISSN
- 0302-9530
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The usefulness of doxorubicin (DXR) is limited by its cardiotoxicity. In order to improve future DXR therapy by using a new antioxidant agent, an experimental study was designed. This study was undertaken to determine whether DXRβinduced cardiotoxicity is prevented by erdosteine, a muco
Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r