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Protective effect of taurine against renal interstitial fibrosis of rats induced by cisplatin

✍ Scribed by Shin Sato; Jyoji Yamate; Takeshi Saito; Toshiyuki Hosokawa; Shigeru Saito; Masaaki Kurasaki

Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
248 KB
Volume
365
Category
Article
ISSN
0028-1298

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Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r