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The Presenilin 1 Mutation (M146V) Linked to Familial Alzheimer's Disease Attenuates the Neuronal Differentiation of NTera 2 Cells

✍ Scribed by Shinya Tokuhiro; Taisuke Tomita; Hiroshi Iwata; Takuo Kosaka; Takaomi C. Saido; Kei Maruyama; Takeshi Iwatsubo


Book ID
115581818
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
444 KB
Volume
244
Category
Article
ISSN
0006-291X

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To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular concentration of amyloid beta-protein (A beta) ending at A beta 42(43) in vivo, we performed a blinded comparison