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149 The Presenilin 1 and 2 mutations linked to familial Alzheimer's Disease increase the extracellular concentration of amyloid 0 protein (Aβ) ending at Aβ42(43)

✍ Scribed by S. Younkin; D. Scheuner; X. Song; C. Eckman; M. Citron; N. Suzuki; T. Bird; J. Hardy; M. Hutton; L. Lannfelt; E. Levy-Lahad; E. Peskind; P. Poorkaj; G. Schellenberg; R. Tanzi; M. Viitanen; W. Wasco; D. Selkoe


Book ID
118577894
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
152 KB
Volume
17
Category
Article
ISSN
0197-4580

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✍ Scheuner, D.; Eckman, C.; Jensen, M.; Song, X.; Citron, M.; Suzuki, N.; Bird, T. 📂 Article 📅 1996 🏛 Nature Publishing Group 🌐 English ⚖ 764 KB

To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular concentration of amyloid beta-protein (A beta) ending at A beta 42(43) in vivo, we performed a blinded comparison