In osteoarthritis and rheumatoid arthritis the hardness of the subchondral bone of the medial tibial plateau is lower than in normals. In order to further analyse this study of the morphologic characteristics in bone from the mentioned region was carried out in 22 normals, 14 osteoarthritis and 12 r
The presence of alkaline phosphatase in the subchondral bone of the medial tibial condyle in the normal state and in osteoarthritis and rheumatoid arthritis
โ Scribed by Paul Lereim; Anders Linde; Jan F. Goldie
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 355 KB
- Volume
- 83
- Category
- Article
- ISSN
- 1434-3916
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โฆ Synopsis
A study has been carried out on the alkaline phosphatase activity in trabecular bone in the normal state, rheumatoid arthritis and osteoarthritis. Samples were taken from the subchondral bone of the medial tibial condyle in all cases. The reason for this study was to investigate whether changes in rheumatoid bone like trabecular microfractures and healing reactions were paratlelled by a mineralization process which could be demonstrated by an increased alkaline phosphatase activity and compared to that in osteoarthritic and normal bone.
This investigation disclosed that the alkaline phosphatase activity in rheumatoid bone did not differ much from either osteoarthritis or normal bone.
Zusamraen/assung. Eine Untersuchung tiber alkalischen Phosphatasen in den intraspongi-5sen Knochentrabekeln bei Normalf/~llen, Rheumatoid Arthritis und Osteoarthrosis ist durchgefiihrt. In s~mtlichen F/iIlen wurde eine Trabekelmasse yon dem subchondralen Knochert in dem medialen Kondylus der Tibia untersucht. Die Ursache fiir diese Untersuchung war ein Versuch festzustellen, ob die Ver~nderungen im rheumatischen Knochen mit trabe-kul~ren Microfrakturen und die zusammenhangende tteilungsreaktion yon einer ErhShung der alkalischen Phosphatasen als Nachweis eines Mineralizationsprozesses gekennzeichnet werden konnte. Die Resultate wurden mit denen yon Normalf/illen und Osteoarthrosis verglichen.
Die Aktivit~t yon den alkalischen Phosphatasen in den Trabekeln des subchondralen Knochens war in Fiillen yon Rheumatoid Arthritis yon den in Normalf/~llen und Osteoarthrosis nicht verschieden.
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