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Spatial patterns of cartilage loss in the medial femoral condyle in osteoarthritic knees: Data from the osteoarthritis initiative

✍ Scribed by Wolfgang Wirth; Olivier Benichou; C. Kent Kwoh; Ali Guermazi; David Hunter; Reinhard Putz; Felix Eckstein

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
271 KB
Volume
63
Category
Article
ISSN
0740-3194

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✦ Synopsis

The objective of this study was to develop a technique for analyzing spatial patterns of cartilage loss in the medial femoral condyle (MF), and to study MF cartilage loss in participants of the Osteoarthritis Initiative. Using a 0.7mm sagittal double echo at steady state (DESS) sequence, 160 osteoarthritic knees from 80 participants with varying degrees of medial joint space narrowing were imaged at baseline and 1-year follow-up. MF cartilage was segmented and cartilage loss determined. Rate of change varied significantly (P 5 0.0067) along the anterior-posterior extension of the MF, with the greatest changes (245 lm, 22.7%) observed 30-60Β°posterior to the trochlear notch. The rate was greater in the central MF after excluding peripheral aspects of the MF from analysis. Sensitivity to change was greatest at 45-75Β°(standardized response mean 5 20.32) but was minimally affected by medial-lateral trimming. In conclusion, the greatest sensitivity to change was achieved when analyzing the posterior aspect of the central, weight-bearing MF.

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