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The preparation of carbon-14 labelled 1-[4-(2-diethylamino-ethoxy) phenyl]-1, 2-diphenyl-2-chloroethene (clomiphene) and 1-[4-(2-(N-pyrrolidinyl) ethoxy) phenyl]-2-(4-methoxyphenyl)-2-nitro-2-phenylethene (CI-628, nitromiphene)

✍ Scribed by Peter C. Ruenitz; Jerome R. Bagley

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
273 KB
Volume
20
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The preparation of [^14^C] clomiphene and [^14^C] nitromiphene from [methylene‐^14^C] benzyl chloride is described. The overall radio‐chemical yield and specific activity of the former are 53% and 0.53 mCi/mmol and those of the latter are 26% and 0.23 mCi/mmol. The method described is of micromolar scale designed for maintaining cost economy while yielding final products of sufficient radioactivity for in vitro and in vivo metabolism studies.

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