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The preparation of carbon-14 and tritium labelled 1-[4-(2-dimethylaminoethoxy)phenyl]-1, 2-diphenyl-1-butene [ICI 46,474, tamoxifen (‘nolvadex’)] and the separation of cis-trans isomers I. The synthesis of carbon-14 labelled tamoxifen (‘nolvadex’)

✍ Scribed by J Burns; D Rutter (The Late)

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
310 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The preparation of [^14^C]tamoxifen from [U‐^14^C]bromobenzene is described. Several preparations of the compound have been made with overall radiochemical yields of 12% ‐ 14%, and specific activities 1.3 to 10.1 mCi/mmol have been obtained.

The purification procedures used, including the separation of the cis‐trans isomers by preparative thin layer chromatoqraphy, are also described.

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