𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The preparation of carbon- 14 labeled tobacco constituents1. II. The synthesis of D1-nicotine (2′-14C)

✍ Scribed by R. A. Comes; M. T. Core; M. D. Edmonds; W. B. Edwards; R. W. Jenkins Jr.

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
250 KB
Volume
9
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A 3‐step synthesis, of dl‐nicotine (2^1^‐^14^C) is described. Commercially available nicotinamide (carbonyl‐^14^C) is dehydrated to 3‐cyanopyridine (cyano‐^14^C). Reaction of the 3‐cyanopyridine with cyclopropyl lithium yields 3‐pyridyl cyclopropyl ketone (carbonyl‐^14^C) which is converted to dl‐nicotine (2^1^‐^14^C) by refluring in N‐methyl formamide. Gas‐liquid radio‐chromatography is used for cheimical and radiochemical purity determinations.

📜 SIMILAR VOLUMES

The preparation of carbon-14 labeled tob
The preparation of carbon-14 labeled tobacco constituents, I. the syntheses of benzyl, phenethyl, and undecyl acetate-14C-1, 2
✍ R. A. Comes; R. W. Jenkins Jr. 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 French ⚖ 173 KB

was a c c o m p l i s h e d b y t r a p p i n g f r o m 4 g a s chromatograph. The t e c h n i q u e of g a s -l i q u i d r a d i o c h r o m a t o g r a p h y i n a ct i v i t y d e t e r m i n a t i o n s i s d e s c r i b e d .

Synthesis of carbon-14 labeled [1-14C]-,
Synthesis of carbon-14 labeled [1-14C]-, and [2-14C]-L-tyrosine
✍ W. Augustyniak; R. Kański; M. Kańska 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 96 KB 👁 1 views

## Abstract Two labeled isotopomers of L‐tyrosine, L‐Tyr, have been synthesized using specific properties of the enzymes phenylanine ammonia lyase, PAL, and L‐phenylalanine hydroxylase. In an intermediate step [1‐^14^C]‐, and [2‐^14^C]‐L‐phenylalanine, L‐Phe, have been obtained from [1‐^14^C]‐, and

Synthesis of carbon-14 labeled 1,4-benzo
Synthesis of carbon-14 labeled 1,4-benzodiazepnies. II.(1) diazepam-14C, demethyldiazepam-14C, and ketazolam-14C
✍ Richard S. P. Hsi 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 287 KB 👁 1 views

## Abstract Diazepam‐^14^C and demethyldiazepam‐^14^C are synthesized from glycine‐1‐^14^C. Addition of diketene to diazepam‐^14^C leads to ketazolam‐^14^C. The reaction conditions for the formation of ketazolam from diazepam is studied using high‐pressure liquid chromatography in conjunction with

The new “one-flask” synthesis of 14C lab
The new “one-flask” synthesis of 14C labelled 1-bromoalkanes - synthesis of 1-bromo [1-14c] heptane
✍ Tomáš Elbert; Jiří Filip 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 407 KB 👁 1 views

Conditions were found for almost quantitative carboxylation of n-hexyllithium with l4CO2 to afford lithium [1-l4C] heptanoate. It was then possible to perform the reaction sequence lithium [1-l4C] heptanoate --+ [l-14C] heptan-1-01 + 1-bromo [l-14q heptane in one flask without isolation of intermed

Preparation of ring labelled adamantane
Preparation of ring labelled adamantane derivatives II. 2-adamantanone-2−14C, adamantane-2−14C and 1-methyladamantane-2 or 4−14C
✍ Samuel H. Liggero; Zdenko Majerski; Paul von R. Schleyer; A. P. Wolf; C. S. Redv 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 368 KB 👁 1 views

A high-yield, relatively simple synthetic route leading to incorporation of l'C into the secondary position of the adamantane nucleus is described. The synthesis was achieved by the sequence shown in Figure 2. The key steps involved the introduction of a I4C label by diazome1hane-14C ring expansion