The possible role of phospholipase A2in hepatic microsomal lipid peroxidation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats
โ Scribed by Z. A. F. Al-Bayati; S. J. Stohs
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 647 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0090-4341
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The exhalation of ethane is widely used as an indicator of in vivo lipid peroxidation. To test the hypothesis that lipid peroxidative events are involved in the toxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), we administered a lethal dose of TCDD (60 micrograms/kg), IP to male Sprague-Daw
The distribution of iron, copper, zinc, and magnesium in hepatic subcellular fractions of male and female rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was determined. Animals received 40 micrograms TCDD per kilogram per day for three days by mouth (po) or the vehicle and were killed