2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced lipid peroxidation in hepatic and extrahepatic tissues of male and female rats
โ Scribed by Zainab A. F. Al-Bayati; Wallace J. Murray; Sidney J. Stohs
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 803 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0090-4341
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Dederrioxamine (DFX), an iron chelator. has been used to inhibit In v i m redox cycling of the transition iron ions that may interfere with free-radical formation, and is used clinically to treat conditions associated with iron overload. The effect of DFX on hepatic iron distribution has not been ex
The exhalation of ethane is widely used as an indicator of in vivo lipid peroxidation. To test the hypothesis that lipid peroxidative events are involved in the toxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), we administered a lethal dose of TCDD (60 micrograms/kg), IP to male Sprague-Daw