Effects of vitamins E and A on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced lipid peroxidation and other biochemical changes in the rat
β Scribed by Mohammad Q. Hassan; Sidney J. Stohs; Wallace J. Murray
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 591 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0090-4341
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## Abstract The administration of single oral doses of 200 ΞΌg kg^β1^ of 2,3,7,8βtetrachlorodibenzoβ__p__βdioxin to females of the outbred, Lac: P strain of rat results in the formation of hepatic multinucleate cells by cell fusion. Liver cell plasma membranes isolated 6 or 11 days after dosing show
## Abstract An acutely toxic dose of 2,3,7,8βtetrachlorodibenzoβ__p__βdioxin (TCDD) leads to a drastically and permanently reduced feed intake and wasting by an unknown mechanism. We focused on the possible interference of TCDD with hypothalamic factors known to take part in the regulation of eatin