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The permissive effect of p21Waf1/Cip1 on DNA synthesis is dependent on cell type: Effect is absent in p53-inactive cells

✍ Scribed by Robert H Weiss; Collette J Randour


Book ID
114283471
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
249 KB
Volume
12
Category
Article
ISSN
0898-6568

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p21WAF1/Cip1 expression is associated wi
✍ Nadal, Alfons; Jares, Pedro; Cazorla, Maite; FernΓ‘ndez, Pedro L.; Sanjuan, Xavie πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 513 KB

p21 WAF1/Cip1 is a recently identified gene involved in cell cycle regulation through cyclin-CDK-complex inhibition. The expression of this gene in several cell lines seems to be induced by wild-type, but not mutant, p53. p21 WAF1/Cip1 expression has been studied at both mRNA and protein levels in a