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p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx

✍ Scribed by Nadal, Alfons; Jares, Pedro; Cazorla, Maite; Fernández, Pedro L.; Sanjuan, Xavier; Hernández, Lluis; Pinyol, Magda; Aldea, Martí; Mallofré, Carme; Muntané, Jaume; Traserra, José; Campo, Elías; Cardesa, Antonio

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
513 KB
Volume
183
Category
Article
ISSN
0022-3417

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✦ Synopsis

p21 WAF1/Cip1 is a recently identified gene involved in cell cycle regulation through cyclin-CDK-complex inhibition. The expression of this gene in several cell lines seems to be induced by wild-type, but not mutant, p53. p21 WAF1/Cip1 expression has been studied at both mRNA and protein levels in a series of 49 normal mucosae and squamous cell carcinomas of the larynx. A significant association was found between mRNA and protein expression in tumours (P<0•0001). p21 WAF1/Cip1 expression was strongly associated with squamous cell differentiation of carcinomas, because six of seven (86 per cent) undifferentiated carcinomas (grade 4) showed very low levels of p21 WAF1/Cip1 expression, whereas 41 out of 42 (98 per cent) carcinomas with squamous cell differentiation (grades 1-3) had normal or high levels of p21 WAF1/Cip1 expression (P<0•0001). In addition, p21 WAF1/Cip1 expression was topologically related to the squamous differentiation of tumour cells with a distribution similar to that seen in normal squamous epithelium. No correlation was found between p21 WAF1/Cip1 expression and the global S-phase of the carcinomas. p53 mutations (exons 5-9) were found in ten carcinomas with p21 WAF1/Cip1 expression, but no p53 mutations were detected in three p21 WAF1/Cip1 -negative tumours. In conclusion, p21 WAF1/Cip1 expression is frequently upregulated in squamous cell carcinomas of the larynx and is associated with tumour cell differentiation. p21 WAF1/Cip1 expression in these tumours is independent of p53 gene mutations. 1997

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