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The p53/p21Cip1/ Waf1 pathway mediates the effects of SPARC on melanoma cell cycle progression

✍ Scribed by Nina Fenouille; Guillaume Robert; Mélanie Tichet; Alexandre Puissant; Maeva Dufies; Stéphane Rocchi; Jean-Paul Ortonne; Marcel Deckert; Robert Ballotti; Sophie Tartare-Deckert

Book ID
118074904
Publisher
Wiley (Blackwell Publishing)
Year
2010
Tongue
English
Weight
731 KB
Volume
24
Category
Article
ISSN
1755-1471

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✍ Katerina Pardali; Marcin Kowanetz; Carl-Henrik Heldin; Aristidis Moustakas 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 724 KB

## Abstract Transforming growth factor‐β (TGF‐β) inhibits epithelial cell growth, in part via transcriptional induction of the cell cycle inhibitor p21^WAF1/Cip1^ (p21). We show that bone morphogenetic protein (BMP)‐7 induces higher p21 expression than TGF‐β1 in various epithelial cells. Despite th