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Regulation of an inhibitor of the cell cycle, p21WAF1CIP1 by the ubiquitin-proteasome pathway

✍ Scribed by Jérôme Boulaire; Dominique Canella; Denis Rousseau; Patrick Fitzgerald; Arun Fotedar; Rati Fotedar

Book ID
114192188
Publisher
Portland Press
Year
1999
Tongue
English
Weight
169 KB
Volume
91
Category
Article
ISSN
0248-4900

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✍ Katerina Pardali; Marcin Kowanetz; Carl-Henrik Heldin; Aristidis Moustakas 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 724 KB

## Abstract Transforming growth factor‐β (TGF‐β) inhibits epithelial cell growth, in part via transcriptional induction of the cell cycle inhibitor p21^WAF1/Cip1^ (p21). We show that bone morphogenetic protein (BMP)‐7 induces higher p21 expression than TGF‐β1 in various epithelial cells. Despite th