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Enhanced cell cycle progression and down regulation of p21Cip1/Waf1 by PRL tyrosine phosphatases

✍ Scribed by Sean R. Werner; Paul A. Lee; Matthew W. DeCamp; Dring N. Crowell; Stephen K. Randall; Pamela L. Crowell


Book ID
117467975
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
460 KB
Volume
202
Category
Article
ISSN
0304-3835

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## Abstract Transforming growth factor‐β (TGF‐β) inhibits epithelial cell growth, in part via transcriptional induction of the cell cycle inhibitor p21^WAF1/Cip1^ (p21). We show that bone morphogenetic protein (BMP)‐7 induces higher p21 expression than TGF‐β1 in various epithelial cells. Despite th