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The procyanidin-mediated induction of apoptosis and cell-cycle arrest in esophageal adenocarcinoma cells is not dependent on p21Cip1/WAF1

✍ Scribed by R. Pierini; P.A. Kroon; S. Guyot; I.T. Johnson; N.J. Belshaw


Book ID
116334837
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
179 KB
Volume
270
Category
Article
ISSN
0304-3835

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## Abstract Butyric acid is well recognized as a histone deacetylase (HDAC) inhibitor, and changes in histone acetylation are thought to alter gene expression. The mechanism by which sodium butyrate (NaB) induces p21^WAF1/CIP1^, a critical gene involved in the antiproliferative effect of NaB, was s