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Cooperative effect of p21Cip1/WAF−1 and 14-3-3σ on cell cycle arrest and apoptosis induction by p14ARF

✍ Scribed by Hemmati, P G; Normand, G; Gillissen, B; Wendt, J; Dörken, B; Daniel, P T


Book ID
109970515
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
923 KB
Volume
27
Category
Article
ISSN
0950-9232

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Codon 273 is one of the hot spots of missense mutation of the p53 tumor suppressor gene found in human cancers. We have previously reported that a mutation at codon 273, p53-273L (Arg 3 Leu), suppresses cell growth despite its having no p53-specific transactivation activity. To further elucidate the