## Abstract Three cases of familial polyposis coli with adenomatous polyps of the upper gastro-intestinal tract are reported. This association has not previously been described in Britain, probably because no special attempt has been made to detect polyps in these situations. A careful study of kn
The occult osteomatous changes in the mandible in patients with familial polyposis coli
β Scribed by Joji Utsunomiya; Tadashi Nakamura
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 529 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0007-1323
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β¦ Synopsis
Abstract
Characteristic radio-opaque lesions were detected in the mandibular bone, most clearly on the panoramic X-ray, in 27 or 93Β·2 per cent out of 29 cases in 15 families with familial polyposis coli, including 21 cases without Gardner's stigmata, 7 cases with the incomplete syndrome and 1 with the complete syndrome.
Only 3 out of 19 members of these families who were free from polyposis had radio-opaque jaw lesions. The cases with polyposis of other types also showed a negative result.
The radiological diagnosis suggested that the lesions were of the character of endosteoma. Our observation is considered to be significant evidence in the understanding of the pathogenesis of Gardner's syndrome as well as a useful method for the early detection of carriers in the polyposis family.
π SIMILAR VOLUMES
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm
## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with