Polyposis of the stomach and small intestine in association with familial polyposis coli
โ Scribed by D. C. Hoffmann; J. C. Goligher
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 336 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0007-1323
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โฆ Synopsis
Abstract
Three cases of familial polyposis coli with adenomatous polyps of the upper gastro-intestinal tract are reported. This association has not previously been described in Britain, probably because no special attempt has been made to detect polyps in these situations.
A careful study of known cases of polyposis coli is required to establish the frequency and fate of associated gastric or small intestinal polyps, with particular reference to the risk of malignant degeneration and the possibility of prophylactic surgical measures.
๐ SIMILAR VOLUMES
Abstract Forty-nine patients undergoing surgery for familial polyposis coli (FPC) over a twenty year period are presented. Forty-three patients underwent total colectomy with ileorectal anastomosis (TC + IRA) and five patients subsequently developed a rectal carcinoma. The incidence of rectal carcin
## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with