Gastric hamartomatous polyps in the absence of familial polyposis coli
β Scribed by Dr. Masaharu Tatsuta; Shigeru Okuda; Hiroshi Tamura; Haruo Taniguchi
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 577 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0008-543X
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## Abstract Three cases of familial polyposis coli with adenomatous polyps of the upper gastro-intestinal tract are reported. This association has not previously been described in Britain, probably because no special attempt has been made to detect polyps in these situations. A careful study of kn
## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm
Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T