The Mutation Spectrum of theAPCGene in Turkish Patients with Familial Adenomatous Polyposis
β Scribed by Berrin Tunca; Gulsah Cecener; Unal Egeli; Abdullah Zorluoglu; Tuncay Yilmazlar
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 302 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0012-3706
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π SIMILAR VOLUMES
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm
Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua