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The molecular mechanism of inhibition of interleukin-1β-induced cyclooxygenase-2 expression in human synovial cells byTripterygium wilfordiiHook F extract

✍ Scribed by K. Maekawa; N. Yoshikawa; J. Du; S. Nishida; H. Kitasato; K. Okamoto; H. Tanaka; Y. Mizushima; S. Kawai


Book ID
105753908
Publisher
SP Birkhäuser Verlag Basel
Year
1999
Tongue
English
Weight
278 KB
Volume
48
Category
Article
ISSN
1420-908X

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Objective. The cyclooxygenase (COX) metabolite, 15-deoxy-⌬ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), has been reported to inhibit the expression of a number of genes involved in the pathogenesis of arthritis. However, its effects on COX-2 remain controversial. We undertook this study to investigate the