The nuclear transcription factor NF-κB mediates interleukin-1β–induced expression of cyclooxygenase-2 in human myometrial cells
✍ Scribed by Andrew R. Belt; Joseph J. Baldassare; Miklós Molnár; Roberto Romero; Frank Hertelendy
- Book ID
- 113986510
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 252 KB
- Volume
- 181
- Category
- Article
- ISSN
- 1097-6868
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## Abstract IL‐1β is an important mediator in the pathogenesis of type 1 diabetes both in vivo and in vitro and it has been shown to induce islet β‐cell apoptosis. Most of the IL‐1β effects seem to be mediated by NF‐κB transcription factor activation, but its role in the induction of islet β‐cell a
## Abstract Increased myometrial expression of cyclooxygenase‐2 (Cox‐2) at term results from elevated local levels of inflammatory cytokines, and its inhibition provides a potential route for intervention in human pre‐term labor. We have identified a role for atypical protein kinase C (PKC) isozyme