The Membrane-Microfilament Linker Ezrin Is Involved in the Formation of the Immunological Synapse and in T Cell Activation
✍ Scribed by Anne Roumier; Jean C Olivo-Marin; Monique Arpin; Frédérique Michel; Marianne Martin; Paul Mangeat; Oreste Acuto; Alice Dautry-Varsat; Andrés Alcover
- Book ID
- 117723134
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 710 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1074-7613
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The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. A
## Abstract ## Objective Leflunomide, a potent disease‐modifying antirheumatic drug of the isoxazole class, exhibits antiinflammatory, antiproliferative, and immunosuppressive effects by largely unknown mechanisms, although alterations of pyrimidine synthesis have been proposed. Successful immune