A key intermediate for the synthesis of isocarbacyclin, a promising therapeutic agent for cardiovascular and circulatory disorders, has been synthesized from (&J-(+)-methyl 2-oxo-l-cyclopentaneacetate by employing rhodium(II)-catalyzed intramolecular C-H insertion reaction of a-diazo B-keto ester as
The intramolecular thermal ene reaction route to (+)-9(O)-methano-Δ6(9α) -PGI1
✍ Scribed by Yuji Ogawa; Masakatsu Shibasaki
- Book ID
- 104232549
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 231 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A synthesis of dl-9(O)-methano-A 6(9a)\_pGI 1 (1\_), a more potent prostacyclin analog than carbacyclin, has been accomplished utilizing regiocontrolled transformation of the enone to the olefin via the allylsilane as a key step.
## (O)-methano-A 6(9a)_pGI has been synthesized by utilizing the regiocontrolled cleavage of the B-propio&one tiith the dialkylaluminum acetylide.
A method for the conversion of aldehydes to acetylenes via I-alkenylstannanes is reported, including its application to the synthesis of 9(O)-thia-A6-PCIl. In connection with studies directed toward the synthesis of prostacyclin analogs, it was required to develop a mild method for the transformati