✦ LIBER ✦

Chiral synthesis of isocarbacyclin ((+)-9(0)-methano-Δ6(9α)-PGI1) intermediate via rhodium(II)-catalyzed intramolecular CH insertion reaction

✍ Scribed by Shun-ichi Hashimoto; Tomohiro Shinoda; Yasunaga Shimada; Takeshi Honda; Shiro Ikegami

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 274 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)95800-3

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✦ Synopsis

A key intermediate for the synthesis of isocarbacyclin, a promising therapeutic agent for cardiovascular and circulatory disorders, has been synthesized from (&J-(+)-methyl 2-oxo-l-cyclopentaneacetate by employing rhodium(II)-catalyzed intramolecular C-H insertion reaction of a-diazo B-keto ester as a key step.