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Regiocontrolled conversion of α,β-unsaturated ketones to olefins via allylsilanes: synthesis of d1-9(0)-methano-Δ6(9α)-PGI1

✍ Scribed by Masakatsu Shibasaki; Hidemi Fukasawa; Shiro Ikegami

Book ID: 104219993
Publisher: Elsevier Science
Year: 1983
Tongue: French
Weight: 204 KB
Volume: 24
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)86022-0

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✦ Synopsis

A synthesis of dl-9(O)-methano-A 6(9a)_pGI 1 (1_), a more potent prostacyclin analog than carbacyclin, has been accomplished utilizing regiocontrolled transformation of the enone to the olefin via the allylsilane as a key step.

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