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The intramolecular silyl modified sakurai (ISMS) reaction. A novel and highly convergent synthesis of oxocenes

✍ Scribed by Abdelaziz Mekhalfia; István E Markó; Harry Adams

Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 248 KB
Volume: 32
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)92307-4

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✦ Synopsis

By employing the intramolecular version of the SMS reaction, oxocenes, including spiroethers and spiroketals, can be prepared in a highly convergent, one-step operation.

In the preceding communicationl, we have described our initial findings on a novel and powerful methodology -The Silyl Modified Sakurai (SMS) reaction -for the preparation of homoallylic ethers directly from carbonyl derivatives. We envisoned that the intramolecular variant of the SMS reaction might provide a simple and efficient route towards the synthesis of spiroethers and spiroketals*.

In this Letter, we report some of our results on the successful

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