✦ LIBER ✦

The influence of reducing agents on the composition of99Tc-complexes: Implications for99mTc-radiopharmaceutical preparation

✍ Scribed by John Baldas; John Bonnyman; Peter M. Pojer; Geoffrey A. Williams

Publisher: Springer
Year: 1982
Tongue: English
Weight: 256 KB
Volume: 7
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00443930

No coin nor oath required. For personal study only.

✦ Synopsis

The use of formamidine sulphinic acid as a reducing agent in the presence of technetium-99-pertechnetate and diethyldithiocarbamate ligand has been shown to yield a complex containing a Tc = CO bond. The carbon monoxide present in this complex originates from the reducing agent itself. Evidence is presented which suggests that this carbonyl complex is present in the 99mTc-diethyldithiocarbamate preparation obtained by the use of formamidine sulphinic acid as the reducing agent. Use of hydrazine as a reducing agent yields a complex containing a Tc = N bond. It is apparent that when reducing agents such as hydrazine or formamidine sulphinic acid are used in the preparation of 99mTc-radiopharmaceuticals, the possibility of the formation of complexes structurally different to those obtained by the use of stannous chloride must be considered.

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