𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A new efficient method for the preparation of 99mTc-radiopharmaceuticals containing the TcN multiple bond

✍ Scribed by Roberto Pasqualini; Veronique Comazzi; Emmanuel Bellande; Adriano Duatti; Andrea Marchi

Publisher
Elsevier Science
Year
1992
Weight
387 KB
Volume
43
Category
Article
ISSN
0883-2889

No coin nor oath required. For personal study only.

✦ Synopsis

An improved method for the preparation of 99mTc-radiopharmaceuticals containing the TEN multiple bond, in sterile and apyrogen conditions, is described. This method is based on the reaction of [99mTc]pertechnetate with ligands derived from S-methyl dithiocarbazate [H2N--N(R)~C(=S)SCH 3 (R = H, CH3] , in the presence of HC1 and tertiary phosphines. It was found that these derivatives can behave both as sources of nitride nitrogen ions (N 3-) and as coordinating ligands. The reaction leads to the formation of intermediate technetium-nitrido complexes in high yield. These intermediate species can be used as suitable prereduced substrates for the preparation of technetium-nitrido radiopharmaceuticals through simple substitution reactions with appropriate exchanging ligands.

📜 SIMILAR VOLUMES

The preparation of substitution-inert 99
The preparation of substitution-inert 99Tc metal-fragments: Promising candidates for the design of new 99mTc radiopharmaceuticals
✍ Francesco Tisato; Marina Porchia; Cristina Bolzati; Fiorenzo Refosco; Andrea Vit 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 525 KB

99 Tc mixed-ligand complexes displaying characteristic substitution-inert metal-fragments are emerging as alternative platforms in the design of potential 99m Tc radiopharmaceuticals. Starting from the already well-known [Tc(CO) 3 ] + moiety, this review describes recent efforts in the coordination

Synthesis and characterization of new 99
Synthesis and characterization of new 99mTc-radiopharmaceuticals with dithiobenzoate derivatives for the study of septic inflammatory processes
✍ F. Mevellec; A. Roucoux; N. Noiret; A. Moisan; H. Patin; A. Duatti 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 128 KB

Improved methods for the preparation of 99m Tc-radiopharmaceuticals containing dithiobenzoate ligands, in sterile and pyrogen free conditions, are described. These procedures are based on the reaction of these ligands either with [ 99m Tc] pertechnetate in the presence of a strong reducing agent (HC

A New General Method for the Preparation
A New General Method for the Preparation of N-Sulfonyloxaziridines.
✍ Jose Luis Garcia Ruano; Jose Aleman; Cristina Fajardo; Alejandro Parra 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 26 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.