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Synthesis and characterization of new 99mTc-radiopharmaceuticals with dithiobenzoate derivatives for the study of septic inflammatory processes

✍ Scribed by F. Mevellec; A. Roucoux; N. Noiret; A. Moisan; H. Patin; A. Duatti

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
128 KB
Volume
46
Category
Article
ISSN
0022-2135

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✦ Synopsis

Improved methods for the preparation of 99m Tc-radiopharmaceuticals containing dithiobenzoate ligands, in sterile and pyrogen free conditions, are described. These procedures are based on the reaction of these ligands either with [ 99m Tc] pertechnetate in the presence of a strong reducing agent (HCl/ tertiary phosphine, SnCl 2 Á 2H 2 O), or with pre-reduced complexes obtained from different kit formulations. All the preparations led to the high-yield formation of the neutral and lipophilic 99m Tc-complex [ 99m Tc][Tc(S 3 CPh) 2 (S 2 CPh)], which is analogous to the corresponding compounds obtained with rhenium and the long-lived b-emitting isotope technetium-99 g recently described. HPLC analysis and thin layer chromatography were used to confirm the characterisation of the resulting 99m Tc-radiopharmaceutical which was found to be potentially suitable for blood-cell labelling as applied to the

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