The preparation of substitution-inert 99Tc metal-fragments: Promising candidates for the design of new 99mTc radiopharmaceuticals

✍ Scribed by Francesco Tisato; Marina Porchia; Cristina Bolzati; Fiorenzo Refosco; Andrea Vittadini

• Publisher: Elsevier Science
• Year: 2006
• Tongue: English
• Weight: 525 KB
• Volume: 250
• Category: Article
• ISSN: 0010-8545
• DOI: 10.1016/j.ccr.2006.01.022

✦ Synopsis

99 Tc mixed-ligand complexes displaying characteristic substitution-inert metal-fragments are emerging as alternative platforms in the design of potential 99m Tc radiopharmaceuticals. Starting from the already well-known [Tc(CO) 3 ] + moiety, this review describes recent efforts in the coordination chemistry of technetium aiming at the exploitation of the metal-fragment strategy. Examples include Tc III '4 + 1' and Tc III 'SSS' systems, along with a description of the Tc V (N)(PNP) system and the transfer of this technology to other cores (M NPh and M O).