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Application of a macromolecular Sn (II) complex to the preparation of 99mTc radiopharmaceuticals

✍ Scribed by Morio Nakayama; Takaaki Terahara; Masao Wada; Kumiko Harada; Atsushi Sugii; Hiroaki Egawa

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
405 KB
Volume
43
Category
Article
ISSN
0021-8995

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✦ Synopsis

To develop insoluble Sn2+ complexes for the preparation of 99mTc radiopharmaceuticals, the adsorption of Sn2+ to macroreticular chelating ion exchange resins having various functional groups was investigated. Among them, a resin containing aminophosphonic acid groups showed a high adsorption capacity for Sn2+, which was bound strongly to the resin by chelation. This macromolecular Sn2+ complex was very stable against hydrolysis and oxidation, and could be applied satisfactorily for the reduction of 99mTc.

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