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The influence of fibrin(ogen) fragments on the kinetic parameters of the tissue-type plasminogen-activator-mediated activation of different forms of plasminogen

✍ Scribed by Willem NIEUWENHUIZEN; Marijke VOSKUILEN; Anton VERMOND; Bep HOEGEE-de NOBEL; Daan W. TRAAS


Book ID
115125779
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
593 KB
Volume
174
Category
Article
ISSN
1432-1327

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit