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Study of tissue-type plasminogen activator binding sites on fibrin using distinct fragments of fibrinogen

✍ Scribed by Patrick GRAILHE; Willem NIEUWENHUIZEN; Eduardo ANGLÉS-CANO

Book ID
115130651
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
842 KB
Volume
219
Category
Article
ISSN
1432-1327

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit