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Stimulation of the amidolytic activity of single chain tissue-type plasminogen activator by fibrinogen degradation products: possible fibrin binding sites on single chain tissue-type plasminogen activator molecule

✍ Scribed by Tetsumei Urano; Yumiko Takada; Akikazu Takada

Book ID
113268613
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
660 KB
Volume
1077
Category
Article
ISSN
0167-4838

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit