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An experimental and theoretical study on the dissolution of mural fibrin clots by tissue-type plasminogen activator

✍ Scribed by David M. Wootton; Aleksander S. Popel; B. Rita Alevriadou

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
574 KB
Volume
77
Category
Article
ISSN
0006-3592

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit