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1 A new model that describes the kinetics of fibrin-stimulated plasminogen activation by native and variant tissue-type plasminogen activators


Book ID
114201125
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
135 KB
Volume
10
Category
Article
ISSN
0268-9499

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit