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Identification of a site in fibrin(OGEN) which is involved in the acceleration of plasminogen activation by tissue-type plasminogen activator

✍ Scribed by Willem Nieuwenhuizen; Anton Vermond; Marijke Voskuilen; Daan W. Traas; Jan H. Verheijen


Book ID
113264092
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
491 KB
Volume
748
Category
Article
ISSN
0167-4838

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit