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The Influence of Fasting on the Synthesis of Cholesterol, Squalene, Fatty Acids, and Ubiquinones in Liver, Small Intestine, and Kidney of Rats in vivo

✍ Scribed by Oswald; Verena Wiss

Publisher
John Wiley and Sons
Year
1977
Tongue
German
Weight
577 KB
Volume
60
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The existence of a regulating site of the cholesterol synthetic pathway in rat liver located after the squalene formation is shown by a comparison of the incorporation of labelled acetate and mevalonate in vivo over a period from 7.5 minutes to several hours under fasting and non fasting conditions. The existence of such a regulating site becomes also evident by the influence of fasting on the incorporation of labelled squalene into the cholesterol of the liver.

It is assumed that enzymes acting between acetylcoenzyme A and mevalonate, e.g. the HMG‐coenzyme‐A reductase regulate the flux of substrate in direction squalene with the tendency to keep it constant. Such an assumption is in agreement with the observed minor influence of fasting on the squalene and ubiquinone synthesis.

It could be shown, that the cholesterol synthesis in the kidneys is regulated by the same mechanism as in liver, whereas such a regulation could be excluded in the small intestine.

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