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Influence of in vivo copper on MR images of the liver in rats

✍ Scribed by Tsunenori Nakakoshi; Nobuyuki Fujita; Kan Jong-Hon; Noritoshi Takeichi; Kazuo Miyasaka


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
558 KB
Volume
4
Category
Article
ISSN
1053-1807

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✦ Synopsis


Abstract

To investigate the effects of in vivo copper on magnetic resonance (MR) images, the authors studied Long‐Evans cinnamon rats, which develop hepatitis and hepatocellular carcinoma as a result of abnormal copper metabolism. The livers of the rats were imaged before hepatitis developed; the absence of hepatic disease was confirmed histopathologically. The copper that accumulated in the liver of the rats was thought to exist in the form of divalent ions, which were suspected of reducing the T1 and T2 of neighboring protons. However, the signal intensities of the liver on T1‐ and T2*‐weighted images did not change, suggesting that in vivo copper, even when accumulated abnormally, does not influence the signal intensity of MR images.


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