## Abstract The existence of a main regulation site(s) of the cholesterol synthesis located after the squalene formation is demonstrated by cholesterol feeding with labelled glucose, acetate, mevalonate as precursors and by measuring the incorporation rates into cholesterol, squalene, ubiquinones,
Influence of in vivo copper on MR images of the liver in rats
✍ Scribed by Tsunenori Nakakoshi; Nobuyuki Fujita; Kan Jong-Hon; Noritoshi Takeichi; Kazuo Miyasaka
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 558 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
To investigate the effects of in vivo copper on magnetic resonance (MR) images, the authors studied Long‐Evans cinnamon rats, which develop hepatitis and hepatocellular carcinoma as a result of abnormal copper metabolism. The livers of the rats were imaged before hepatitis developed; the absence of hepatic disease was confirmed histopathologically. The copper that accumulated in the liver of the rats was thought to exist in the form of divalent ions, which were suspected of reducing the T1 and T2 of neighboring protons. However, the signal intensities of the liver on T1‐ and T2*‐weighted images did not change, suggesting that in vivo copper, even when accumulated abnormally, does not influence the signal intensity of MR images.
📜 SIMILAR VOLUMES
MORITAKA Go'ro, SHINGO TSIJJI,' TOMOKI MICHIDA,' SHENG-SONG CHEN,' TORU KASHIWAGI,' The purpose of this study was to evaluate the role of endothelin-1 in modulating hepatic microcirculation and liver damage. Rats were infused with endothelin-1 at doses ranging from 30 to 1,000 pmolkg over 1 min thr
## Abstract ## Purpose: To develop a protocol which optimizes contrast, resolution and scan time for three‐dimensional (3D) imaging of the human eye in vivo using a 7 Tesla (T) scanner and custom radio frequency (RF) coil. ## Materials and Methods: Initial testing was conducted to reduce motion
## Abstract Small nodular lesions in the liver and spleen have been reported as an infrequent manifestation of sarcoidosis. Five patients with this appearance on either dynamic contrast material—enhanced computed tomographic (CT) or ultrasound scans underwent magnetic resonance (MR) imaging with an
## Abstract ## Purpose: To examine the long‐term consequences of manganese exposure due to the use of manganese‐enhanced magnetic resonance imaging (MEMRI) in a model of closed head injury, the fluid‐percussion injury (FPI) model. ## Materials and Methods: Two groups of adult male Wistar rats (_