✦ LIBER ✦

On the Influence of Cholesterol Feeding and of a Lipogenic Diet on the Cholesterogenesis in Rat Liver in vivo

✍ Scribed by Oswald; Verena Wiss

Publisher: John Wiley and Sons
Year: 1977
Tongue: German
Weight: 590 KB
Volume: 60
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19770600819

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The existence of a main regulation site(s) of the cholesterol synthesis located after the squalene formation is demonstrated by cholesterol feeding with labelled glucose, acetate, mevalonate as precursors and by measuring the incorporation rates into cholesterol, squalene, ubiquinones, and fatty acids in rat liver in vivo.

By administration of labelled squalene in vivo it is shown that the isoprenic synthesis is inhibited between squalene and lanosterol but that other regulation site(s) after the lanosterol formation must exist.

A regulation site of the cholesterogenesis in rat liver located after the squalene synthesis is also shown after a lipogenic diet administered during 5 days. The cholesterol synthesis is thus reduced to about one third of the control rats. Another regulating site controlling the utilization of acetylcoenzyme A for the synthesis of mevalonate is also shown to exist. No indication was obtained for a regulating influence located between mevalonate and squalene.

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