The influence of endotoxin-induced inflammation on the enantioselective phannacokinetics of propranolol, oxprenolol, and verapamil, which bind to a,-acid glycoprotein, was studied in the rat. The racemic mixtures were given orally. In the control animals, for propranolol and oxprenolol, the plasma c
The influence of aging on the stereoselective pharmacokinetics of propranolol in the rat
β Scribed by An M. Vermeulen; Frans M. Belpaire; Emmanuel Moerman; Frits De Smet; Marc G. Bogaert
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 669 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0899-0042
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Endotoxemia decreases the dose requirement for anesthetics but no data are available for propofol. A rat model was used in which the influence of endotoxin administration on the pharmacokinetics and pharmacodynamics of propofol was investigated. Chronically instrumented rats were randomly allocated