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The effect of administration of propranolol on the pharmacokinetics of isoxicam

✍ Scribed by G. Caillé; L. Larivière; Y. Lacasse; M. Vézina; J. G. Besner

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
326 KB
Volume
7
Category
Article
ISSN
0142-2782

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✦ Synopsis

In order to examine a potential interaction between isoxicam and propranolol, single 200 mg doses of isoxicam were administered to ten healthy male volunteers before and during treatment with propranolol, gradually attaining a dose of 80 mg t.i.d. for 11 days. The pharmacokinetic profiles of the isoxicam plasma concentration/time data obtained over 96 h following the doses of isoxicam before and during propranolol administration were compared. No significant change was found in any of the pharmacokinetic parameters determined. These results suggest that propranolol has no effect on the metabolic disposition of isoxicam.

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