𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The effect of age on the pharmacokinetics of pentisomide

✍ Scribed by D. W. Holt; S. Walker; A. Johnston; R. W. Jones; N. L. Howse; A. Darragh; E. Caffrey

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
239 KB
Volume
12
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

The effects of age on the pharmacokinetics of pentisomide (CM7857), an orally effective antiarrhythmic agent, were studied in two groups of volunteers. Sixteen young volunteers (mean age 26.4 years) and 10 elderly volunteers (mean age 67.8 years) received a single 200 mg oral dose of pentisomide. Mean AUC was larger and terminal elimination half-life longer in the elderly subjects, due to a decrease in total plasma clearance of pentisomide in the elderly. This decrease was due to a reduction in renal clearance of the drug which was paralleled by a significantly lower creatinine clearance in the elderly subjects. Dosage reduction, or a reduced frequency of dosing of pentisomide would be necessary in the elderly or those with impaired renal function.

πŸ“œ SIMILAR VOLUMES

The effect of age on the pharmacokinetic
The effect of age on the pharmacokinetics of valsartan
✍ A. Sioufi; F. Marfil; A. Jaouen; J. M. Cardot; J. Godbillon; F. Ezzet; P. Lloyd πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 162 KB πŸ‘ 2 views

Twelve young (mean age 23 years, range 18-28) and 12 elderly (mean age 76 years, range 65-89) volunteers were given a single oral dose of 80 mg valsartan after an overnight fast. Each group consisted of six male and six female subjects. Mean systemic exposure to valsartan was higher in the elderly w

Evaluation of the effect of food on the
Evaluation of the effect of food on the pharmacokinetics of avitriptan
✍ P. H. Marathe; D. S. Greene; G. D. Kollia; R. H. Barbhaiya πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 272 KB πŸ‘ 2 views

Bioavailability of avitriptan was found to decrease significantly when administered 5 min after a standard high fat meal. The studies described herein were carried out to gain insight into the mechanism of this food effect. A series of studies were conducted in humans to assess the effect of timing

The effect of administration of proprano
The effect of administration of propranolol on the pharmacokinetics of isoxicam
✍ G. CaillΓ©; L. LariviΓ¨re; Y. Lacasse; M. VΓ©zina; J. G. Besner πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 326 KB πŸ‘ 1 views

In order to examine a potential interaction between isoxicam and propranolol, single 200 mg doses of isoxicam were administered to ten healthy male volunteers before and during treatment with propranolol, gradually attaining a dose of 80 mg t.i.d. for 11 days. The pharmacokinetic profiles of the iso

The effect of administration of phenytoi
The effect of administration of phenytoin on the pharmacokinetics of isoxicam
✍ Dr G. CaillΓ©; P. du Souich; L. LariviΓ¨re; M. VΓ©zina; Y. Lacasse πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 258 KB πŸ‘ 1 views

This study was designed to determine whether the disposition of isoxicam is influenced by the coadministration of another acidic drug, highly bound to plasma proteins and extensively metabolized, i.e., phenytoin. Ten healthy volunteers received an oral dose of 200mg of isoxicam prior to and followin