The identification of immunomodulatory approaches that allow the induction of antigen-specific unresponsiveness is required for long-term graft survival without the complications of chronic immunosuppression. Recent novel strategies based upon treatment with synthetic peptides corresponding to linea
The induction of tolerance to alloantigens using MHC class I molecules
β Scribed by Kathryn J. Wood
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 507 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0952-7915
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he allele-specific peptidebinding motifs of major histocompatibility complex (MHC) proteins, originally discovered by pool sequencing of MHC class I-bound peptides 1 , provide a biochemical basis for the phenomenon of MHC restriction of T-cell responses. However, the analysis of class II peptide mot
## Abstract ## Background and Objective Photodynamic therapy (PDT) is FDAβapproved antiβcancer modality for elimination of early disease and palliation in advanced disease. PDT efficacy depends in part on elicitation of a tumorβspecific immune response that is dependent on cytotoxic T lymphocytes