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The induction of tolerance to alloantigens using HLA-based synthetic peptides

✍ Scribed by Alan M. Krensky; Carol Clayberger

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 715 KB
Volume: 6
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(94)90086-8

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✦ Synopsis

The identification of immunomodulatory approaches that allow the induction of antigen-specific unresponsiveness is required for long-term graft survival without the complications of chronic immunosuppression. Recent novel strategies based upon treatment with synthetic peptides corresponding to linear sequences of MHC class I and II molecules reproducibly induce tolerance to alloantigens. Although the mechanisms involved are still not completely understood, the phenomenology reported makes these approaches promising for evaluation in clinical trials.

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